IG4 is a subclass of IgG and comprises only 4% of IgG antibodies. IgG4 serves as an indicator of the extent of allergen exposure and is produced after long-term exposure to an antigen. Unlike IgG, higher IgG4 may be a positive. When the IgG4 reaction is greater than the IgE reaction for a particular antigen, IgG4 may block the IgE antibodies from binding to the receptor sites and releasing histamine, thereby reducing the severity of the symptoms associated with the IgE reaction. IgG4 antibodies not only block IgE mediated allergies but also block the reactions of other IgG subclasses, reducing inflammatory reactions caused by other IgG subclasses.
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